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Options include partial reconstitution (if feasible with your vial format), freezing portions of reconstituted solution (accepting some potency loss), or adjusting your dose higher to use everything before expiration

However, the absence of toxicity signals in animal models does not guarantee equivalent safety in humans, and long-term safety data in human populations does not currently exist

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Mechanistically, ferroptosis is driven by the accumulation of lethal phospholipid hydroperoxides (PL-OOH), primarily derived from polyunsaturated fatty acid (PUFA)-containing phospholipids